Bioinformatics
MA324: Introduction to Bioinformatics (5 ECTS)
This module provides biology students with foundation knowledge of bioinformatics and enables them to perform basic bioinformatic tasks. It will also introduce them to the scope for further learning and more advanced applications, and allow them to appreciate how bioinformatic tools are fundamental to modern medicine.
Taught in Semester(s) II. Examined in Semester(s) II.
Workload: 109 hours (12 Lecture hours, 22 Lab hours, 75 Self study hours).
Module Learning Outcomes.
On successful completion of this module the learner should be able to:
- Access types of molecular sequence data and resources from a spectrum of databases.
- Implement essential bioinformatics algorithms by hand.
- Differentiate and relate key bioinformatics analytical approaches individually and as a complementary toolkit.
- Compare and contrast the computational analysis of data generated by different molecular biology technologies.
- Evaluate the importance of different molecular biology data generation technologies to medicine.
Indicative Content
- Biological databases and online resources
- Genome browsers/accessing genomic data
- Sequence alignment
- Phylogenetics
- Sequence homology
- Gene-to-protein expression
- Gene expression bioinformatics
- Population structure and genetics
- Genome-wide association studies
- Personal genomics and ancestry
- Medical genomics
- Systems biology
Module Resources
- DW Mount Bioinformatics; sequence and genome analysis, CSHL Press
- AD Baxevanis & BFF Oullette Bioinformatics – A practical guide to the analysis of genes and proteins, Wiley
- AM Lesk Introduction to Bioinformatics, Oxford
- http://www.rjr-productions.org/Networks/Contents.html David A Morrison
- Introduction to phylogenetic networks
- Understanding Bioinformatics Zvelebil M, Baum JO
- Bioinformatics from genomes to therapies Lengauer T
- EBI portal http://www.ebi.ac.uk/2can/home.html
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